Eli Lilly currently has one FDA-approved drug specifically for weight loss:
- Zepbound (tirzepatide): This is a once-weekly injectable medication approved for adults with obesity (BMI ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2) with at least one weight-related comorbid condition.
Zepbound contains tirzepatide, a dual GIP and GLP-1 receptor agonist that helps reduce appetite and food intake, leading to weight loss. It is recommended to use Zepbound in conjunction with a reduced-calorie diet and increased physical activity.
Important notes about Zepbound
- Dosage: Zepbound is available in various doses administered via single-dose pens or vials.
- Cost and Access: Eli Lilly is working to improve Zepbound’s coverage and affordability and offers a commercial savings card program for eligible individuals to potentially lower out-of-pocket costs. Single-dose vials are also available through their LillyDirect Self Pay Pharmacy Solutions.
- Side Effects: Common side effects are gastrointestinal, such as nausea, diarrhea, and vomiting. Serious side effects are possible and include thyroid tumors (including cancer), pancreatitis, gallbladder problems, kidney problems, serious allergic reactions, changes in vision (for people with type 2 diabetes), and depression or suicidal thoughts. It is important to discuss potential side effects and risks with your doctor.
- Not for Cosmetic Use: Zepbound is not intended for cosmetic weight loss.
- Pregnancy: Zepbound may be harmful during pregnancy. If you become pregnant while taking Zepbound, consult your healthcare provider immediately. A pregnancy exposure registry is available for those who have taken Zepbound during pregnancy.
Eli Lilly’s pipeline
Eli Lilly also has other potential weight-loss drugs in development:
- Orforglipron: An oral GLP-1 drug showing promise in clinical trials for type 2 diabetes and weight loss, potentially offering a convenient alternative to injectables. Regulatory approval is expected in the near future.
- Retatrutide: A “triple-G” drug targeting GLP-1, GIP, and glucagon, which appears to be even more effective for weight loss than tirzepatide.
- Bimagrumab and Eloralintide: Other experimental drugs in development, with Bimagrumab potentially helping to protect muscle mass during weight loss.
Always consult a healthcare professional to determine if Zepbound or any other weight loss treatment is appropriate for you based on your health needs and medical histor
